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E! News host Giuliana Rancic has faced many hard times. Not only has she struggled with infertility and cancer, the Fashion Police star, 40, has recently undergone another devastating personal blow.

Giuliana and husband Bill Rancic, who welcomed son Duke via surrogate in 2012, learned on New Year’s Eve that their surrogate — who was pregnant with their third and last remaining embryo — had miscarried.

“It was painful,” Giuliana tells PEOPLE. “We were so optimistic with this last embryo. We thought, ‘This is definitely going to work. This is our last shot.’ ”

After welcoming Duke, now 2, the couple had three remaining embryos. Two were successfully implanted in their surrogate in 2014, but unfortunately she miscarried weeks later. The last miscarriage “was the toughest blow,” Giuliana admits. “It was a really hard time.”

But the couple have not given up hope on expanding their family.

“We’re open to everything,” says Giuliana, whose memoir, Going Off Script, hits shelves April 7.

“I think adoption is a beautiful gift you’re giving each other,” she adds. “And it’s funny, I’m even more open to [adoption] than I was before. Because I think to myself, ‘I love Duke so much, if I couldn’t take care of him, I hope there would be someone else who would love him.’ ”

Prior to welcoming Duke via surrogate, Giuliana went through three rounds of IVF treatments before finding out she had breast cancer. The couple put their plans to start a family on hold while Giuliana underwent a double mastectomy.

After beating cancer, the Rancics turned to Delphine, the surrogate who would later deliver Duke.