Hayden Panettiere3

Spy witnesses tell The Globe’s Loosch Lips Column that the Heroes cutie – known for her environmental and humanitarian efforts – curtly refused to sign an autograph for a male fan who approached her as she exited a flight.

A jet-lagged Hayden was headed home after a press junket in New York City for her new film, I Love You, Beth Cooper.

“Get a life and a real job,” Hayden allegedly snarled at the autograph seeker.

“She was so nasty and insulting to the poor guy for no apparent reason,” says one astounished snitch. “It’s not like she was being hounded by a bunch of people.”